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GlossaryTelomere Shortening

gradual reduction of protective chromosome ends during cell division

Telomere shortening refers to the gradual reduction in the length of telomeres, which are protective caps at the ends of chromosomes. Each time a cell divides, its telomeres become slightly shorter, eventually leading to cellular aging and dysfunction when they become critically short. This process is also known as telomere attrition and is a key factor in aging and age-related diseases.

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research Local Artemis Dysfunction May Be One Molecular Mechanism for Androgenetic Alopecia via Telomere Shortening

July 2012 in “Medical Hypotheses”

Artemis dysfunction might cause hair loss through telomere shortening.

research Skin and Hair Follicle Aging: From Clinical Characterization to Functional Study

1 citations , April 2015 in “Munich Personal RePEc Archive (Ludwig Maximilian University of Munich)”

Skin and hair aging involves mitochondrial issues, telomere shortening, and hormonal changes, with iron affecting hair loss in pre-menopausal women.

research Telomere Dysfunction Impairs Epidermal Stem Cell Specification and Differentiation by Disrupting BMP/pSmad/P63 Signaling

19 citations , September 2019 in “PLOS genetics”

Telomere damage affects skin and hair follicle stem cells by messing up important growth signals.

research Replicative Stress, Stem Cells, and Aging

70 citations , March 2008 in “Mechanisms of Ageing and Development”

Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.

research Do Changes in Chromosomes Cause Aging?

50 citations , July 1996 in “Cell”

Chromosomal changes, including those in the WRN gene and rDNA, may significantly contribute to aging.

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community Hair loss research is a money grab

in Chat 227 upvotes 3 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community In my opinion baldness is more prevalent now and it's being ignored..

in Chat 236 upvotes 2 years ago

The conversation is about the prevalence of baldness among young men and the potential factors contributing to it. Specific treatments mentioned include minoxidil and finasteride.

community Hyperbaric Oxygen Therapy (HBOT)

in Research/Science 7 upvotes 3 years ago

Hyperbaric Oxygen Therapy (HBOT) is discussed as a potential treatment for androgenic alopecia due to its ability to reverse hypoxia and promote angiogenesis. The conversation explores its potential benefits for hair loss, though no studies have been conducted on this application yet.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 43 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community 2.5 yrs progress: Min + dermaroll + niz

in Progress Pictures 76 upvotes 3 years ago

A user's 2.5 year hair loss progress with Minoxidil, dermarolling, and Nizoral treatments, as well as taking biotin and a multivitamin supplement, with the intention of trying DIY topical finasteride in the future.

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