95 citations
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September 2012 in “Oman Medical Journal” The document reviewed the structure and function of keratins, which are structural proteins crucial for maintaining the integrity of keratinocytes. It highlighted that humans have around 30 keratin families, divided into acidic and basic groups, with 54 functional genes coding for them. These keratins are expressed in specific patterns depending on epithelial type and differentiation stage. Mutations in keratin genes were linked to tissue fragility disorders affecting skin and mucosa. Keratins serve as differentiation markers, with antibodies to keratin aiding in diagnostic pathology. The review also focused on keratinization disorders, particularly in the oral cavity, and noted the clinical significance of keratin.
211 citations
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April 2018 in “Cold Spring Harbor Perspectives in Biology” Keratins are crucial for cell structure, growth, and disease risk.
40 citations
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November 2021 in “International Journal of Molecular Sciences” Mutant keratins cause inflammation in Epidermolysis Bullosa Simplex, suggesting targeting them could help treat the disorder.
13 citations
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December 2019 in “Nutrients” An apple-based supplement was found to stimulate hair protein production, which may help with hair growth.
60 citations
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December 2003 in “Journal of Investigative Dermatology” K6hf is found in specific parts of hair follicles, nails, and tongue, and is linked to hair growth and structure.