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Immunoreactivity of the SARS-CoV-2 Entry Proteins ACE-2 and TMPRSS-2 in Murine Models of Hormonal Manipulation, Aging, and Cardiac Injury

research Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury

5 citations , December 2021 in “Scientific Reports”

Age affects how certain proteins involved in COVID-19 infection are expressed in mice, but sex hormones and heart injury do not.

research Finasteride Induces Epigenetic Alteration of TMPRss2 Gene Expression: A Potential role in Severe Acute Respiratory Syndrome-Corona Virus-2 Inhibition

May 2023

Finasteride may help reduce COVID-19 infection by altering a key gene.

research Spiking dependence of SARS‐CoV‐2 pathogenicity on TMPRSS2

30 citations , February 2021 in “Journal of Medical Virology”

TMPRSS2 affects COVID-19 severity and treatment options.

The Antiandrogen Enzalutamide Downregulates TMPRSS2 and Reduces Cellular Entry of SARS-CoV-2 in Human Lung Cells

research The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells

50 citations , July 2021 in “Nature Communications”

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

research ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-COV-2 in Cancer Patients

38 citations , January 2020 in “Cell Transplantation”

Targeting ACE2 and TMPRSS2 may help prevent or treat COVID-19 in cancer patients.

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community Adrogens and Covid-19

in Treatment 7 upvotes 5 years ago

The possible increased risk of severe Covid-19 cases in men due to higher androgen levels, and how taking medications such as finasteride, dutasteride, spironolactone, enzalutamide, or canabidiol might help mitigate the severity of the disease.

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