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GlossaryTopical Calcineurin Inhibitors

medications applied to skin to reduce immune responses

Topical Calcineurin Inhibitors (TCIs) are medications applied to the skin to reduce inflammation and immune responses. They work by blocking the activity of calcineurin, a protein that activates T-cells in the immune system, making them useful in treating conditions like eczema and vitiligo. Unlike corticosteroids, TCIs do not cause skin thinning, making them a safer long-term option for sensitive areas.

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Research

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research Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus

9 citations , February 2011 in “Biologics: Targets & Therapy”

Topical calcineurin inhibitors, especially 0.1% tacrolimus ointment, are effective and well-tolerated for treating cutaneous lupus erythematosus but require more research for standard treatment guidelines.

Scalp Atrophy Secondary to Steroid Use in Patients With Scarring Alopecia: Are Topical Steroids Superior to Topical Calcineurin Inhibitors?

research Scalp atrophy secondary to steroid use in patients with scarring alopecia: are topical steroids superior to topical calcineurin inhibitors?

1 citations , November 2023 in “International Journal of Dermatology”

Topical calcineurin inhibitors might be safer than steroids for scarring alopecia, but more research is needed.

research Resolution of Discoid Lupus Alopecia With Systemic Hydroxychloroquine and Topical Pimecrolimus Combination Therapy

June 2024 in “Cureus”

Combining hydroxychloroquine and pimecrolimus can effectively treat hair loss from discoid lupus.

research Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence

19 citations , May 2021 in “Clinical, Cosmetic and Investigational Dermatology”

Minoxidil and finasteride are the best for non-scarring hair loss; more research is needed for scarring hair loss treatments.

research Common Topical Medications

October 2018 in “Springer eBooks”

The document concludes that various topical medications are effective for skin conditions but often cause skin irritation as a side effect.

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community Topical - Lantoprost .01%, MIN 10% DUT .05%, Hydrocortisone 1% Progrestron .025%

in Treatment 6 upvotes 11 months ago

A user was prescribed a topical treatment for hair loss including Latanoprost, Minoxidil, Dutasteride, Hydrocortisone, and Progesterone, after using an oral Minoxidil and Finasteride combo without significant results. Concerns were raised about the long-term use of hydrocortisone, with suggestions to consult a doctor regularly.

community I had claude create a protocol only using fda approved drugs.

in Research/Science 4 upvotes 6 months ago

A new hair loss protocol using FDA-approved topical treatments targets eight pathways, potentially improving results by 60-75% compared to the standard 40-50% from oral minoxidil and finasteride. The protocol includes minoxidil, finasteride, tacrolimus, cetirizine, bimatoprost, lithium gluconate, losartan, melatonin, NAC, caffeine, and tretinoin, with a monthly cost of $35-50 in Mexico and $80-150 in the US.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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learn Calcipotriene

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