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GlossaryTranscription Factors

proteins that regulate gene expression by binding to DNA

Transcription Factors (TFs) are proteins that help turn specific genes on or off by binding to nearby DNA. They play a crucial role in regulating gene expression, ensuring that genes are activated at the right time and in the right cells, which is essential for processes like development, cell growth, and response to environmental signals.

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research The transcription elongation factors Spt4 and Spt6 promote dermal adipocyte differentiation

March 2026 in “Adipocyte”

Spt4 and Spt6 are essential for fat cell development.

research 0866 Role of transcriptional elongation in dermal fat development

July 2025 in “Journal of Investigative Dermatology”

Nelfb is essential for dermal fat development and survival.

research ROOT HAIR DEFECTIVE SIX‐LIKE4 (RSL4) promotes root hair elongation by transcriptionally regulating the expression of genes required for cell growth

75 citations , July 2016 in “New phytologist”

The protein RSL4 is crucial for making root hairs longer by controlling genes related to cell growth.

research SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation

April 2026 in “Cellular and Molecular Immunology”

SPT6 prevents excessive skin inflammation by blocking a feedback loop.

research Study of seed hair growth in Populus tomentosa, an important character of female floral bud development

20 citations , June 2014 in “BMC genomics”

Poplar seed hairs grow from the placenta at the ovary base, with endoreduplication playing a key role in their development, and share similar cellulose synthesis processes with cotton fibers.

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