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GlossaryTRPV2

protein channel in cells activated by heat and stress

TRPV2 is a type of protein found in the cell membranes that acts as an ion channel, allowing certain ions like calcium to pass into the cell. It is activated by high temperatures and mechanical stress, playing a role in various physiological processes, including pain perception and the regulation of hair growth.

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research Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes

77 citations , September 2017 in “Journal of Investigative Dermatology”

TRPV3 in skin cells causes inflammation and cell death.

research Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole

28 citations , September 2021 in “EMBO reports”

Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.

research Molecular determinants for the chemical activation of the warmth-sensitive TRPV3 channel by the natural monoterpenoid carvacrol

24 citations , February 2022 in “Journal of Biological Chemistry”

Carvacrol activates the TRPV3 channel, which may help design new skin treatments.

research Mechanisms of proton inhibition and sensitization of the cation channel TRPV3

15 citations , December 2020 in “The Journal of General Physiology”

Acid can block TRPV3 from outside the cell but boost its function from inside.

research TRPV Channels in Osteoarthritis: A Comprehensive Review

14 citations , February 2024 in “Biomolecules”

TRPV channels are important in osteoarthritis and could be key to new treatments.

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