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GlossaryTRPV4

protein channel regulating calcium flow in cells

TRPV4 is a type of protein found in the cell membranes that acts as an ion channel, allowing calcium and other ions to pass into the cell. It plays a crucial role in various physiological processes, including the regulation of skin barrier function, hair growth, and response to mechanical and osmotic stress. Dysfunction in TRPV4 can be linked to certain skin and hair disorders, as well as other medical conditions.

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research Localization of mechanosensitive channel TRPV4 in mouse skin

123 citations , November 2003 in “Neuroscience Letters”

TRPV4 helps sense pressure in mouse skin.

research TRPV3 as a Therapeutic Target for Itch

88 citations , April 2012 in “Journal of Investigative Dermatology”

Blocking TRPV3 may help treat itch in dry skin conditions.

research Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes

77 citations , September 2017 in “Journal of Investigative Dermatology”

TRPV3 in skin cells causes inflammation and cell death.

Influence of TRPV3 Mutation on Hair Growth Cycle in Mice

research Influence of TRPV3 mutation on hair growth cycle in mice

59 citations , September 2007 in “Biochemical and Biophysical Research Communications”

The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.

research Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole

28 citations , September 2021 in “EMBO reports”

Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.

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