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GlossaryTumorigenesis

process of normal cells transforming into cancerous tumors

Tumorigenesis, also known as tumor formation, is the process by which normal cells transform into cancer cells and begin to grow uncontrollably, forming a mass or tumor. This process involves a series of genetic mutations and changes in cellular behavior that allow the cells to evade normal growth controls, resist cell death, and often gain the ability to invade surrounding tissues and spread to other parts of the body.

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research Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis

65 citations , November 2013 in “The EMBO Journal”

HDAC1 is crucial for skin development and preventing tumors.

research Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine

40 citations , August 2018 in “Disease Models & Mechanisms”

Mature cells can re-enter the cell cycle and potentially lead to cancer.

Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis

research Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis

29 citations , July 2014 in “PloS one”

Meis1 is crucial for skin health and tumor development.

research Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch

8 citations , August 2014 in “Biochemical and Biophysical Research Communications”

ODC overexpression in hair cells increases tumor growth by reducing Notch signaling.

Mammary Cells with Active Wnt Signaling Resist ErbB2-Induced Tumorigenesis

research Mammary Cells with Active Wnt Signaling Resist ErbB2-Induced Tumorigenesis

8 citations , November 2013 in “PLOS ONE”

Cells with active Wnt signaling are less likely to turn into cancer when exposed to a cancer-causing gene.

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