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Proteomic Analysis Identifies Differentially Expressed Proteins Participating in Forming Type III Brush Hair in Yangtze River Delta White Goat

research Proteomic analysis identifies differentially expressed proteins participating in forming Type III brush hair in Yangtze River Delta white goat

8 citations , January 2015 in “Genetics and molecular research”

Researchers found four key proteins that affect the development of a specific hair type in Yangtze River Delta white goats.

research Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients.

11 citations , May 1996 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

research The 5α-Recluctase System and Its Inhibitors

124 citations , January 1996 in “Dermatology”

5 alpha-reductase inhibitors, like finasteride, are used to treat conditions like prostate issues and skin disorders.

Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

research Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

16 citations , February 2007 in “Plastic and Reconstructive Surgery”

Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.

research Steroid 5α-reductases and 3α-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism

115 citations , March 2001 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

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community 5ar alpha reductase stimulation is different depending on whether it’s type 1 or 2

in Hair Systems 17 upvotes 3 years ago

The conversation discusses how different factors can stimulate type 1 and type 2 isoforms of 5-alpha reductase, which are enzymes linked to hair loss. Specific treatments mentioned include oral Dutasteride and topical Finasteride.

community Painkillers May Block Minoxidil

in Research/Science 14 upvotes 1 year ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community My Theory Of Androgenic Alopecia

in Research/Science 20 upvotes 8 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 209 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community I reduced my serum DHT by 60% without Fin/Dut but not seeing any real stabilization or growth

in Update 2 upvotes 10 months ago

The user reduced serum DHT by 60% using Advanced Trichology's natural DHT blocker but saw no improvement in hair loss. They are considering switching to finasteride due to its proven effectiveness in inhibiting scalp DHT.

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learn Dutasteride

Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity

learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Overview

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