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Elucidating the Roles of Three β-Glucuronosyltransferases Acting on Arabinogalactan-Proteins Using a CRISPR-Cas9 Multiplexing Approach in Arabidopsis

research Elucidating the roles of three β-glucuronosyltransferases (GLCATs) acting on arabinogalactan-proteins using a CRISPR-Cas9 multiplexing approach in Arabidopsis

28 citations , May 2020 in “BMC plant biology”

The study concluded that three enzymes are important for plant development by affecting sugar composition and calcium binding in plants.

In Vitro Selective Inhibition of Human UDP-Glucuronosyltransferase (UGT) 1A4 by Finasteride and Prediction of In Vivo Drug–Drug Interactions

research In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug–drug interactions

13 citations , November 2014 in “Toxicology Letters”

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models

research Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

38 citations , June 2018 in “Archives of Toxicology”

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Anti-Inflammatory Effects in LPS-Treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-San

research Anti-inflammatory Effects in LPS-treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-san

December 2021 in “Daehanhanuihakoeji”

The traditional herbal formulas Yongdamsagan-Tang and Paljung-san, along with the drug finasteride, can reduce inflammation and may work together without affecting each other's effectiveness against benign prostatic hyperplasia.

Testicular Steroidogenesis: Production and Regulation of Testosterone and Dihydrotestosterone

research Testicular Steroidogenesis

5 citations , January 2017 in “Endocrinology”

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

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community Is 0.1%w/v topical fin overkill if taking oral 0.5mg fin?

in Finasteride/Dutasteride 2 upvotes 5 months ago

The conversation discusses whether using 0.1% topical finasteride alongside 0.5 mg oral finasteride is excessive, with suggestions to choose either oral or topical treatment. The user also uses 5% minoxidil and mentions concerns about alcohol-based solutions due to seborrheic dermatitis.

community Anyone here using Minoxidil (5% w/v) + Finasteride (0.1% w/v) spray? I see that most of you are using oral tablets. :/

in Treatment 2 upvotes 3 years ago

User discusses using a Minoxidil (5% w/v) + Finasteride (0.1% w/v) spray for hair loss, along with Logifeel Hair Spray, Trichoton Forte tablets, and Zycafy Shampoo. They seek experiences with sprays as most use oral tablets.

community Best reversing hairloss protocol i’v seen - do you trust it?

in Treatments 104 upvotes 1 year ago

The conversation discusses a hair loss protocol and compares it to using finasteride and minoxidil. It suggests that while the protocol includes some good advice, it may not surpass the effectiveness of established treatments like finasteride and minoxidil.

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