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Did you mean Whole-Exome Sequencing?

GlossaryWhole-Exome Sequencing

sequencing all protein-coding regions of genes in a genome

Whole-Exome Sequencing (WES) is a genomic technique that involves sequencing all the protein-coding regions of genes in a genome, known as exons. These regions make up about 1-2% of the human genome but contain around 85% of known disease-related genetic variants, making WES a powerful tool for identifying genetic mutations associated with various conditions, including alopecia.

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Whole-Genome Sequencing of Eight Goat Populations for the Detection of Selection Signatures Underlying Production and Adaptive Traits

research Whole-genome sequencing of eight goat populations for the detection of selection signatures underlying production and adaptive traits

92 citations , December 2016 in “Scientific Reports”

Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.

research Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype

February 2024 in “BMC genomics”

The TRPV3 gene variant may cause the long-haired suri alpaca coat.

research Whole-genome bisulfite sequencing of goat skins identifies signatures associated with hair cycling

28 citations , August 2018 in “BMC genomics”

DNA methylation changes are linked to hair growth cycles in goats.

research Integrating whole-genome re-sequencing and transcriptome data to reveal the molecular mechanism of TBX5 gene regulating feathered feet in Guangxi native chickens

2 citations , February 2025 in “Poultry Science”

TBX5 gene influences feathered feet in Guangxi chickens by affecting cell growth and movement.

research Whole-genome SNP genotyping mapped a novel locus for hereditary hypotrichosis on chromosome 2q31.1–q32.2

May 2015 in “Journal of Dermatological Science”

Researchers found a new area on chromosome 2 linked to a genetic hair loss condition.

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community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 2 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Journey against alopecia - Finasteride 3 month

in Progress Pictures 18 upvotes 4 years ago

A 26-year-old man from France started experiencing hair loss in September 2020 and began using finasteride in June 2021, reporting some improvement after three months without side effects. He plans to continue finasteride for a year before considering additional treatments like minoxidil or dermarolling.

community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

in Research/Science 24 upvotes 5 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

community How do we only have two treatments to combat hair loss at this point in time?

in Chat 211 upvotes 3 years ago

The post discusses frustration over the limited and not always effective treatments for hair loss, mainly Minoxidil and Finasteride. The conversation includes mentions of potential new treatments like GT20029, HMI-115, CosmeRNA, KX-826, and microneedling, but also highlights the challenges of funding and prioritizing research in this area.

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