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GlossaryWNT10A gene

regulates development of hair, skin, and teeth tissues

The WNT10A gene is a part of the WNT gene family, which plays a crucial role in the development and growth of various tissues in the body, including hair, skin, and teeth. Mutations in this gene can lead to conditions like hypohidrotic ectodermal dysplasia, which is characterized by sparse hair, missing teeth, and reduced ability to sweat.

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Research

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Mutational Spectrum of EDA, EDAR, EDARADD, and WNT10A Genes in the Largest Cohort of Russian Patients With Hypohidrotic Ectodermal Dysplasia

research Mutational spectrum of EDA, EDAR, EDARADD, and WNT10A genes in the largest cohort of Russian patients with hypohidrotic ectodermal dysplasia

February 2026 in “Orphanet Journal of Rare Diseases”

Most genetic mutations causing hypohidrotic ectodermal dysplasia in Russian patients are found in the EDA gene.

research The Expressions Rules of Wnt10b and SFRP2 Gene in Skin of Wanxi Angora Rabbit

January 2013

Wnt10b promotes hair growth, while SFRP2 inhibits it in Wanxi Angora rabbits.

research Biology and Genetics of Hair

89 citations , September 2010 in “Annual Review of Genomics and Human Genetics”

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

research Novel missense mutation in the EDA gene in a family affected by oligodontia

12 citations , January 2016 in “Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie”

Researchers found a new mutation in the EDA gene that likely causes missing teeth and mild skin symptoms in one family.

research WNT10A gene variants at the root of short anagen hair syndrome

1 citations , September 2023 in “British journal of dermatology/British journal of dermatology, Supplement”

WNT10A gene mutations cause short anagen hair syndrome.

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community My understanding of how androgenetic alopecia works (plus FIN and DUT)

in Research/Science 17 upvotes 4 years ago

Androgenetic alopecia is affected by scalp DHT levels, not sensitivity, with treatments like finasteride and dutasteride aiming to optimize these levels. Personalized DHT management is crucial for effective hair growth.

community Better Than Minoxidil? Topical Sodium Valproate

in Research/Science 53 upvotes 1 year ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

community A Theory on Why Microneedling Works

172 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

community Natural Remedies: Polyphenols and Hair Loss

20 upvotes 7 years ago

Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

community Do you keep gains if you stop microneedling?

in Microneedling 15 upvotes 11 months ago

Stopping microneedling may result in losing hair gains, as it enhances the effectiveness of treatments like minoxidil. Combining microneedling with minoxidil and finasteride is more effective than using microneedling alone.

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learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

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17
Hair System Specialist
Jane Genesi
Marlton, PA, United States

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Jane Genesi