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GlossaryWnt3

protein involved in cell signaling crucial for hair growth

Wnt3 is a protein that plays a crucial role in cell signaling pathways, which are essential for various developmental processes in the body, including the growth and maintenance of hair follicles. It is part of the Wnt family of proteins, which are involved in regulating cell fate, proliferation, and migration. In the context of hair biology, Wnt3 signaling is important for the activation and cycling of hair follicles, and disruptions in this pathway can contribute to conditions like alopecia (hair loss).

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Research

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research WNT Signaling in the Control of Hair Growth and Structure

271 citations , March 1999 in “Developmental biology”

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

260 citations , June 2011 in “Cell”

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

207 citations , March 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

research The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

89 citations , November 2017 in “Journal of Cellular Physiology”

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.