A preview of selected articles

July 2020 in “ Stem Cells Translational Medicine ”

Stuart P. Atkinson

TLDR Regulatory T cells can help treat diseases, and a stem cell solution may improve hair growth.

This document highlighted the role of regulatory T cells (Tregs) in modulating immune responses and their potential therapeutic applications in autoimmune diseases, cancer, and organ transplantation. It also discussed the influence of Tregs in traumatic brain injury and host vs. graft reactions. Additionally, the document addressed hair follicle biology, emphasizing the regulation of hair growth cycles and the impact of dysregulation on hair loss. It presented research on a topical solution of adipose stem cell extract as a promising treatment for androgenetic alopecia, showing increased hair density and thickness. Furthermore, it explored the role of Hes1 in maintaining hair cycle homeostasis through Hedgehog signaling.

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A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia

research A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia

25 citations , May 2020 in “Stem Cells Translational Medicine”

ADSC-CE treatment safely increases hair density and thickness in androgenetic alopecia patients.

research Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling

20 citations , November 2019 in “Stem Cells”

Hes1 protein is important for hair growth and regeneration, and could be a potential treatment for hair loss.

research Tregs: Where We Are and What Comes Next?

130 citations , November 2017 in “Frontiers in Immunology”

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss

research Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss

30 citations , June 2017 in “Current stem cell research & therapy”

Adipose-derived stem cells (fat cells) show promise in treating hair loss in both men and women.

research Sexual Side Effects of 5-Alpha-Reductase Inhibitors Finasteride and Dutasteride: A Comprehensive Review

21 citations , January 2017 in “Dermatology Online Journal”

Finasteride and dutasteride can cause sexual problems like impotence and low libido.

research Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study

83 citations , March 2015 in “International Journal of Dermatology”

ADSC-CM treatment improved hair density and thickness in women with hair loss, safely and effectively.

research Quality of Life Assessment in Male Patients with Androgenetic Alopecia: Results of a Prospective, Multicenter Study

101 citations , January 2012 in “Annals of Dermatology”

Men with hair loss experience lower quality of life, worsened by factors like age, severity, and treatment history.

research Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis

61 citations , January 2011 in “PloS one”

Notch signaling is essential for healthy skin and hair follicle maintenance.

research Hair Growth and Rejuvenation: An Overview

81 citations , June 2010 in “Journal of Dermatological Treatment”

The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.