Treatment Advances for Acne Vulgaris: The Scientific Role of Cannabinoids

    February 2024 in “ Cosmetics ”
    Inês C. Ferreira, Carla Martins Lopes, Maria Helena Amaral
    TLDR Cannabidiol shows promise as an effective treatment for acne.
    The review article "Treatment Advances for Acne Vulgaris: The Scientific Role of Cannabinoids" explores the potential of cannabinoids, particularly cannabidiol (CBD), as a novel treatment for acne vulgaris due to their lipostatic, anti-inflammatory, antiproliferative, and antimicrobial properties. Pre-clinical and clinical studies, including a phase 2 trial with 368 patients, have shown that CBD can modulate sebum production, reduce inflammation, and inhibit bacterial growth, making it a promising alternative to conventional acne treatments. The review emphasizes the need for further research to confirm long-term safety, optimal dosages, and the benefits of other cannabinoids and advanced delivery systems like nanotechnology. Despite promising results, regulatory challenges and the need for clinical validation remain significant hurdles.
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