TLDR Alopecia areata helps study T cell-driven autoimmune diseases.
The document discussed alopecia areata as a model for T cell-dependent autoimmune diseases. It highlighted the role of T cells in the pathogenesis of alopecia areata, suggesting that this condition could serve as a valuable model for studying other autoimmune diseases that are also mediated by T cells. The authors emphasized the importance of understanding the immune mechanisms involved in alopecia areata to develop targeted therapies for similar autoimmune conditions.
717 citations
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June 2010 in “Nature” Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.
69 citations
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May 2009 in “Journal of Investigative Dermatology” Stress might contribute to hair loss in alopecia areata.
253 citations
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December 2007 in “Journal of Investigative Dermatology” Hair follicles prevent NK cell attacks to avoid hair loss.
159 citations
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December 2007 in “American Journal of Pathology” Stress-related substance P may lead to hair loss and negatively affect hair growth.
286 citations
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August 2007 in “Journal of Clinical Investigation” Alopecia areata is an autoimmune disease where T cells attack hair follicles.
76 citations
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March 2005 in “Journal of Molecular Medicine” Certain mice without specific receptors or mast cells don't lose hair from stress.
64 citations
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July 1997 in “Journal of The American Academy of Dermatology” Finding eosinophils near hair bulbs helps diagnose alopecia areata.
