Comprehensive Analysis of circRNAs from Cashmere Goat Skin by Next Generation RNA Sequencing (RNA-seq)

January 2020 in “ Scientific Reports ”

Yuanyuan Zheng, Taiyu Hui, Yue Chang, Jiaming Sun, Dan Guo, Suling Guo, Suping Guo, Bojiang Li, Zeying Wang, Wenlin Bai

circular RNAs circRNAs RNA sequencing qPCR circRNAs-miRNAs regulatory network RNA-seq

TLDR Four circRNAs were found to be significantly different in cashmere goat skin, affecting cashmere fineness.

The study conducted a comprehensive analysis of circular RNAs (circRNAs) in cashmere goat skin using next-generation RNA sequencing. Skin samples from Liaoning cashmere goats (LCG) and Inner Mongolia cashmere goats (MCG) were collected during the anagen period. The analysis identified 17 up-regulated and 15 down-regulated circRNAs in LCG compared to MCG. Further qPCR validation on 10 candidate circRNAs in coarse and fine type LCG skin confirmed significant differential expression of four circRNAs: ciRNA128, circRNA6854, circRNA4154, and circRNA3620. A bioinformatically deduced circRNAs-miRNAs regulatory network was proposed to help understand the molecular mechanisms of circRNA involvement in regulating cashmere fineness.

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Research cited in this study

15 / 15 results

research Synchronous Profiling and Analysis of mRNAs and ncRNAs in the Dermal Papilla Cells from Cashmere Goats

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research LncRNAs in Secondary Hair Follicle of Cashmere Goat: Identification, Expression, and Their Regulatory Network in Wnt Signaling Pathway

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research Construction of a cDNA Library and Identification of Genes from Liaoning Cashmere Goat

6 citations , March 2014 in “Livestock science”

Researchers created a genetic library from a cashmere goat's skin and found new genes linked to hair growth.

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223 citations , January 2014 in “International Journal of Molecular Sciences”

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research Identification of MicroRNAs in Wool Follicles During Anagen, Catagen, and Telogen Phases in Tibetan Sheep

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