Targeting the Hallmarks of Aging: Preclinical Evidence and Molecular Mechanisms Underlying the Therapeutic Potential of Centella Asiatica (L.) Urban

This review highlights the therapeutic potential of Centella asiatica (L.) Urban in extending healthspan by targeting the hallmarks of aging. The plant's bioactive compounds, such as asiaticoside and madecassoside, enhance DNA repair, regulate histone modifications, and restore mitochondrial homeostasis, thereby maintaining genomic stability and counteracting metabolic decline. Preclinical studies show that C. asiatica suppresses cellular senescence and systemic inflammation, while also offering neuroprotective and tissue-regenerative benefits through antioxidant mechanisms. These findings suggest that C. asiatica could serve as a foundation for developing multi-target therapies to extend biological healthspan.