Autonomous In Situ Biointerfacing Platform for Real-Time Electrophysiological Monitoring and Advanced Wound Management

The study introduces a novel TLMG hydrogel platform for advanced wound management and real-time electrophysiological monitoring. Composed of tea polyphenols/lignin microspheres, MXene nanosheets, and gelatin, the hydrogel offers robust adhesion, rapid hemostasis, and enhanced wound healing. It promotes skin regeneration by reducing oxidative stress and enhancing angiogenesis, achieving a 93.2% wound closure rate in 10 days in preclinical models. The platform also maintains high-fidelity electrophysiological signal detection under dynamic conditions, showing potential for clinical applications in wound care and bioelectronic monitoring. Further validation in larger animal models and human trials is needed.