Azelaic Acid: Mechanisms of Action and Clinical Applications

October 2024 in “ Clinical Cosmetic and Investigational Dermatology ”

Xiaoyue Feng, J. Shang, Zhengping Gu, Junhua Gong, Yong Chen, Youting Liu

azelaic acid dicarboxylic acid antibacterial anti-keratinizing antimelanogenic antioxidant anti-inflammatory papulopustular rosacea acne vulgaris melasma AZA

TLDR Azelaic acid is effective for treating rosacea, acne, and melasma.

Azelaic acid (AZA) is a naturally occurring dicarboxylic acid with various physiological activities, such as antibacterial, anti-keratinizing, antimelanogenic, antioxidant, and anti-inflammatory effects. It is commonly used in dermatology and is FDA-approved for treating papulopustular rosacea. Additionally, AZA is effective in managing acne vulgaris and melasma. This review highlights the mechanisms of action and clinical applications of AZA, providing theoretical support for its use in clinical and cosmetic settings and encouraging further research.

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Research cited in this study

5 / 5 results

research Hair Follicle-Targeted Delivery of Azelaic Acid Micro/Nanocrystals Promotes the Treatment of Acne Vulgaris

June 2024 in “International journal of nanomedicine”

Azelaic acid micro/nanocrystals, especially with ultrasound and salicylic acid, greatly improve acne treatment.

research Efficacy and Safety of Topical 5% Azelaic Acid Solution Versus 2% Minoxidil Solution in the Treatment of Female Pattern Hair Loss

December 2023 in “Siriraj Medical Journal”

5% Azelaic acid is as effective as 2% Minoxidil for female pattern hair loss and could be an alternative for those allergic to Minoxidil or pregnant.

research The Multiple Uses of Azelaic Acid in Dermatology: Mechanism of Action, Preparations, and Potential Therapeutic Applications

January 2023 in “Postępy Dermatologii i Alergologii”

Azelaic acid treats acne, rosacea, and hyperpigmentation with minimal side effects.

research The Versatility of Azelaic Acid in Dermatology

56 citations , July 2020 in “Journal of Dermatological Treatment”

Azelaic acid is safe and effective for treating rosacea and other skin issues.

research Comparison of Azelaic Acid and Anthralin for the Therapy of Patchy Alopecia Areata

27 citations , January 2005 in “American Journal of Clinical Dermatology”

Azelaic acid and anthralin are similarly effective for treating patchy hair loss.

Similar Research

5 / 307 results

research The Multiple Uses of Azelaic Acid in Dermatology: Mechanism of Action, Preparations, and Potential Therapeutic Applications

January 2023 in “Postępy Dermatologii i Alergologii”

Azelaic acid treats acne, rosacea, and hyperpigmentation with minimal side effects.

research Common Topical Medications

October 2018 in “Springer eBooks”

The document concludes that various topical medications are effective for skin conditions but often cause skin irritation as a side effect.

research A Review of Diagnosis and Treatment of Acne in Adult Female Patients

116 citations , December 2017 in “International Journal of Women's Dermatology”

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

research Azelaic Acid in the Treatment of Acne in Adult Females: Case Reports

11 citations , November 2013 in “Skin Pharmacology and Physiology”

Azelaic Acid is effective and safe for treating adult female acne, with few side effects.

research Treatment of Acne Vulgaris: A Literature Review

1 citations , January 2010 in “Serbian Journal of Dermatology and Venereology”

The document concludes that effective acne treatment requires a personalized combination of therapies and long-term commitment, with retinoids being important for maintenance.

Azelaic Acid: Mechanisms of Action and Clinical Applications

Research cited in this study

research Hair Follicle-Targeted Delivery of Azelaic Acid Micro/Nanocrystals Promotes the Treatment of Acne Vulgaris

research Efficacy and Safety of Topical 5% Azelaic Acid Solution Versus 2% Minoxidil Solution in the Treatment of Female Pattern Hair Loss

research The Multiple Uses of Azelaic Acid in Dermatology: Mechanism of Action, Preparations, and Potential Therapeutic Applications

research The Versatility of Azelaic Acid in Dermatology

research Comparison of Azelaic Acid and Anthralin for the Therapy of Patchy Alopecia Areata

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Similar Research

research The Multiple Uses of Azelaic Acid in Dermatology: Mechanism of Action, Preparations, and Potential Therapeutic Applications

research Common Topical Medications

research A Review of Diagnosis and Treatment of Acne in Adult Female Patients

research Azelaic Acid in the Treatment of Acne in Adult Females: Case Reports

research Treatment of Acne Vulgaris: A Literature Review