Advances in Bioprinting to Model Immune-Mediated Skin Diseases

November 2025 in “ Advanced Healthcare Materials ”

Andrea Ulloa‐Fernández, Marica Marković, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov

bioprinting engineered skin tissue inflammatory skin diseases in vitro models 3Rs framework immune-mediated skin diseases

TLDR Bioprinting is improving skin models for better testing of skin diseases without using animals.

Advancements in bioprinting technologies are enhancing the development of engineered skin tissue models that accurately replicate chronic, non-communicable inflammatory skin diseases. These models aim to reduce reliance on animal testing by providing in vitro alternatives that closely mimic human skin conditions, aligning with the 3Rs framework and legislative efforts. The improved reproducibility, quality, and scalability of bioprinted models hold promise for testing new therapeutic and cosmetic products, particularly in the research of immune-mediated skin diseases.

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Advances in Bioprinting to Model Immune-Mediated Skin Diseases

Research cited in this study

research Modulating Immune Responses in Alopecia: Therapeutic Insights and Potential Targets of Antisense Oligonucleotides

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research Incorporation of hair follicles in 3D bioprinted models of human skin

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research The Human Skin Microbiome in Selected Cutaneous Diseases

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research Stem and Progenitor Cells in Sebaceous Gland Development, Homeostasis, and Pathologies

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