The Use of Botulinum Toxin in the Treatment of Androgenetic Alopecia: A Systematic Review

    January 2026 in “ Dermatologic Therapy
    Anna Zygmunt, Anna Mandecka, Łukasz Mikołaj Karoń, Szymon Leonik, Wiktor Kruczek, Aleksandra Frątczak, Beata Bergler-Czop
    TLDR Botulinum Toxin Type A can increase hair density and improve hair thickness in androgenetic alopecia with minimal side effects.
    This systematic review of 11 studies involving 390 participants evaluates the use of Botulinum Toxin Type A (BoNT-A) for treating androgenetic alopecia (AGA). The findings suggest that BoNT-A can increase hair density by 13%–20% within 12–24 weeks and improve follicle diameter within 3 months, with significant statistical support. BoNT-A works by reducing DHT-induced apoptosis in dermal papilla cells, enhancing scalp vascularization, and potentially reducing scalp sebum secretion. It is generally well-tolerated with minimal adverse effects. While BoNT-A shows promise, particularly when combined with treatments like finasteride and minoxidil, further studies are needed to refine treatment protocols and evaluate long-term outcomes.
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