Topical Carrier-Free Delivery of Finasteride and Peptides for Enhanced Hair Growth

    January 2026 in “ Biomacromolecules
    W K Chung, Ji Eun Kim, Jae Yun Lee, Suin Kim, Woojin Jeong
    TLDR A new topical method using peptides boosts hair growth effectively with less finasteride and fewer side effects.
    The study presents a novel peptide-based, carrier-free topical delivery system for finasteride, aimed at enhancing hair growth while minimizing systemic side effects. This system utilizes a skin- and cell-penetrating peptide with anti-inflammatory properties, which coassembles with finasteride to form nanocomplexes (NCs). These NCs significantly improve dermal papilla cell viability and promote hair regeneration comparable to or exceeding that of 5% minoxidil, despite using approximately 40 times less finasteride than the standard oral dose. Biochemical analyses showed accelerated transition of hair follicles from the catagen to anagen phase, suggesting that this method enhances finasteride efficacy and offers a promising platform for dermatological drug delivery.
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