Screening of circRNAs Associated with Secondary Wool Follicle Development in Fine-Wool Sheep and Construction of Their ceRNA Network

    September 2025 in “ Animals ”
    Yu Luo, Binpeng Xi, Yufang Song, Tong Xiao, Zengkui Lu, Jianbin Liu, Chao Yuan, Tingting Guo
    TLDR Key circRNAs play a role in wool follicle development, aiding in breeding better quality wool sheep.
    This study explores the role of circular RNAs (circRNAs) in the development of secondary wool follicles in fine-wool sheep, focusing on ten embryonic stages in Alpine Merino sheep. Researchers identified 173 differentially expressed circRNAs enriched in pathways crucial for hair follicle development, such as Wnt/β-catenin and Notch. They constructed 88 circRNA–miRNA–mRNA regulatory networks, highlighting 16 key circRNAs, including circRNA_07722 and circRNA_08249, which interact with 44 miRNAs and 65 mRNAs. These findings enhance the understanding of wool growth regulation and offer a theoretical basis for molecular breeding in fine-wool sheep, potentially aiding in the breeding of sheep for higher quality wool.
    Discuss this study in the Community →

    Research cited in this study

    14 / 14 results

    Related Community Posts Join

    6 / 74 results
      What hair loss pattern is this?

      community What hair loss pattern is this?

      in General  157 upvotes 3 months ago
      The user noticed small circular hairless spots after a buzz cut and has been using finasteride, dutasteride, and oral minoxidil for hair loss. They are experiencing continuous shedding and thinning, and it is suggested they consult a dermatologist for a scalp examination and possible biopsy to determine if it's alopecia areata or androgenetic alopecia.

      community Microneedling technique clarification

      in Microneedling  16 upvotes 1 year ago
      The conversation is about using a Dr. Pen for microneedling on a widow's peak, with advice to use a depth of 1.25mm and hold it in place for 10 seconds. The user is also using minoxidil.

      community Scab removal on 8th/9th day...

      in Transplants  14 upvotes 9 months ago
      A user shared their experience with hair transplant scab removal, noting that most scabs came off easily without bleeding by using oil and shampoo. They sought advice on whether any hair was lost during the process, and others reassured them that no hair was lost and to trust the healing process.

    Related Research

    1 / 1 results