Using Qualitative Methods to Establish the Clinically Meaningful Threshold for Treatment Success in Alopecia Areata

July 2022 in “ Quality of Life Research ”

Kathleen W. Wyrwich, Helen Kitchen, S.L. Knight, Natalie V. J. Aldhouse, Jake Macey, Natasha Atanaskova Mesinkovska, Justin Ko, Brett King

alopecia areata SALT score scalp hair regrowth

TLDR 80% scalp hair regrowth is a successful treatment for alopecia areata.

The study used qualitative methods, including interviews with expert clinicians and patients, to determine that achieving 80% or more scalp hair regrowth, corresponding to a SALT score of 20 or less, was considered a clinically meaningful threshold for treatment success in patients with alopecia areata experiencing 50% or more scalp hair loss. This approach effectively established a quantifiable measure of treatment success in alopecia areata.

View this study on escholarship.org →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

Dermatologist and Patient Perceptions of Treatment Success in Alopecia Areata and Evaluation of Clinical Outcome Assessments in Japan

research Dermatologist and Patient Perceptions of Treatment Success in Alopecia Areata and Evaluation of Clinical Outcome Assessments in Japan

7 citations , January 2021 in “Dermatology and therapy”

Both dermatologists and patients in Japan agree that treatment success for alopecia areata is having 20% or less scalp hair loss.

research The Role of Patients in Alopecia Areata Endpoint Development: Understanding Physical Signs and Symptoms

3 citations , October 2020 in “Journal of Investigative Dermatology Symposium Proceedings”

The main goal for new Alopecia Areata treatments should be significant improvement in scalp hair growth.

‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata

research ‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata

30 citations , September 2020 in “Journal of Patient-Reported Outcomes”

Alopecia Areata (AA) causes significant emotional distress, including feelings of embarrassment, depression, and anxiety, and impacts social interactions and daily activities.

Development of Clinician-Reported Outcome and Patient-Reported Outcome Measures for Eyebrow, Eyelash, and Nail Assessment in Alopecia Areata

research Development of Clinician-Reported Outcome and Patient-Reported Outcome Measures for Eyebrow, Eyelash, and Nail Assessment in Alopecia Areata

56 citations , August 2020 in “American Journal of Clinical Dermatology”

New tools help assess eyebrow, eyelash, and nail changes in Alopecia Areata, improving understanding of patient experiences.

research The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials

86 citations , January 2020 in “British Journal of Dermatology”

The AA-IGA scale reliably measures treatment success in alopecia areata by considering both clinician and patient views.

Review of Quality of Life Studies in Women with Alopecia

research Investigative Guidelines for Alopecia Areata

66 citations , May 2011 in “Dermatologic therapy”

Guidelines help design better trials to compare alopecia areata treatments.

Using Qualitative Methods to Establish the Clinically Meaningful Threshold for Treatment Success in Alopecia Areata

Research cited in this study

research Dermatologist and Patient Perceptions of Treatment Success in Alopecia Areata and Evaluation of Clinical Outcome Assessments in Japan

research The Role of Patients in Alopecia Areata Endpoint Development: Understanding Physical Signs and Symptoms

research ‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata

research Development of Clinician-Reported Outcome and Patient-Reported Outcome Measures for Eyebrow, Eyelash, and Nail Assessment in Alopecia Areata

research The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials

research Review of Quality of Life Studies in Women with Alopecia

research Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata

research Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata

research Health-Related Quality of Life Among Patients With Alopecia Areata: A Systematic Review

research Alopecia Areata and Health-Related Quality of Life: A Systematic Review and Meta-Analysis

research Investigative Guidelines for Alopecia Areata