Copper Modulates Mitochondrial Oxidative Phosphorylation to Enhance Dermal Papilla Cell Proliferation in Rex Rabbits

The study found that copper (Cu) at a concentration of 1 nM significantly enhanced the proliferation of dermal papilla cells (DPCs) in Rex rabbits by improving mitochondrial oxidative phosphorylation, particularly through cytochrome c oxidase (Complex IV). This was evidenced by increased intracellular ATP levels and changes in metabolite profiles, including lipid metabolism and arachidonic acid pathways. The research suggested that Cu supports DPC proliferation and could play a role in hair follicle health, although the study did not specify the number of subjects involved.