Deep skin fibroblast-mediated macrophage recruitment supports acute wound healing

    August 2024
    Veronica M. Amuso, MaryEllen R. Haas, Paula O. Cooper, Ranojoy Chatterjee, Sana Hafiz, Shatha Salameh, Chiraag Gohel, Miguel F. Mazumder, Violet Josephson, Khatereh Khorsandi, Anélia Horvath, Ali Rahnavard, Brett A. Shook
    TLDR Deep skin fibroblasts help recruit immune cells for better wound healing.
    This study investigates the role of mesenchymal cells, specifically deep skin fibroblasts, in the early immune response following injury. Using single nuclei RNA-sequencing, researchers found that fibroblasts in deeper skin layers express higher levels of pro-inflammatory genes compared to keratinocytes and myeloid cells. SCA1+ fibroblasts, in particular, were enriched with chemokines like CCL2, CCL7, and IL33. The deletion of the Ccl2 gene in fibroblasts led to a decrease in macrophages and monocytes in the wound bed, resulting in impaired revascularization and re-epithelialization during healing. This highlights the crucial role of deep skin fibroblast-derived factors in inflammation and tissue repair.
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