Development and Optimization of Biotinoyl Tripeptide-1 Loaded Solid Lipid Nanoparticles for Protection Against Heat Induced Hair Damage

This study developed and optimized biotinoyl tripeptide-1 (BTP)-loaded solid lipid nanoparticles (SLNs) to protect hair from heat-induced damage. Using a Box-Behnken design, the researchers optimized the formulation, achieving a particle size of 207.3 nm, PDI of 0.297, zeta potential of -10.6 mV, and entrapment efficiency of 46.2%. Hair samples treated with BTP-SLNs showed improved cuticle integrity, reduced microfibrillary separation, and increased thermal resistance compared to untreated samples. The protective effects are attributed to lipid barrier formation and keratin matrix stabilization, indicating BTP-SLNs as a promising approach for enhancing thermal protection in hair care products.