Comparison of Dermatology Life Quality Index Scores in Adults and Adolescents With Alopecia Areata

April 2025 in “ Dermatology and Therapy ”

Kent A. Hanson, Sergio Vañó‐Galván, Andrew G. Messenger, Helen Tran, Lynne Napatalung, Keith L. Davis, Elizabeth Esterberg, Ernest H. Law

alopecia areata scalp hair loss quality of life AA SHL QOL

TLDR Alopecia areata affects quality of life more in adolescents than adults.

The study found that both adults and adolescents with alopecia areata (AA) experiencing ≥ 50% scalp hair loss (SHL) reported significant impacts on their quality of life (QOL). However, the impact was more pronounced in adolescents compared to adults.

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Research cited in this study

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research The Dermatology Life Quality Index (DLQI) Used as the Benchmark in Validation of 101 Quality-of-Life Instruments: A Systematic Review

18 citations , September 2024 in “Journal of the European Academy of Dermatology and Venereology”

The DLQI is a key tool for measuring quality of life in dermatology.

research Efficacy of the Oral JAK1/JAK2 Inhibitor Deuruxolitinib in Adult Patients with Moderate to Severe Alopecia Areata: Pooled Results from the Multinational Double-Blind, Placebo-Controlled THRIVE-AA1 and THRIVE-AA2 Phase 3 Trials

2 citations , September 2024 in “Journal of the American Academy of Dermatology”

Deuruxolitinib significantly helps regrow scalp hair in adults with moderate to severe alopecia areata.

Real-World Assessment of Disease Characteristics and Clinical Outcomes in Alopecia Areata in a Global Noninterventional Observational Cohort (ADAAGIO)

research Real-World Assessment of Disease Characteristics and Clinical Outcomes in Alopecia Areata in a Global Noninterventional Observational Cohort (ADAAGIO)

March 2024 in “Skin”

Current treatments for alopecia areata often fail to achieve and maintain significant hair regrowth.

research The Invisible Impact Of A Visible Disease: Psychosocial Impact Of Alopecia Areata

40 citations , June 2023 in “Dermatology and Therapy”

Alopecia Areata causes emotional stress and stigma, but those with severe hair loss may adapt better.

research Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial

227 citations , April 2023 in “The Lancet”

Ritlecitinib effectively treats alopecia areata and is well-tolerated.

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

148 citations , March 2022 in “The New England Journal of Medicine”

Baricitinib was effective in treating alopecia areata in two major trials.

‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata

research ‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata

30 citations , September 2020 in “Journal of Patient-Reported Outcomes”

Alopecia Areata (AA) causes significant emotional distress, including feelings of embarrassment, depression, and anxiety, and impacts social interactions and daily activities.

research Alopecia Areata Update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.