Efficacy and Potential Mechanisms of Naringin in Atopic Dermatitis

The study investigates the efficacy of naringin, a flavonoid from Citrus unshiu, as a topical treatment for atopic dermatitis (AD) using a mouse model. Naringin significantly improved AD symptoms by reducing dermatitis severity, epidermal thickness, and mast cell count. It also decreased pro-inflammatory cytokines like IL4, IL13, IFN-γ, and TNF-α, suggesting reduced Th2 immune responses and inflammation. Naringin's antioxidant properties helped inhibit reactive oxygen species and reduce DNA damage. Additionally, it modulated the JAK-STAT signaling pathway, crucial in AD pathogenesis, by reducing the expression of proteins like STAT1, STAT3, and JAK1/2. These findings suggest naringin may offer dual benefits in treating AD by alleviating inflammation and helping restore the skin barrier. However, the study's use of only male mice may limit the generalizability of the results, and further research is needed to explore naringin's effects across different sexes.