Comparative Efficacy of Topical Calcipotriol, Intralesional Autologous Platelet-Rich Plasma Injection, and Combined Topical Calcipotriol with Intralesional Autologous Platelet-Rich Plasma Injection on Patients with Alopecia Areata

September 2025 in “ Journal of Skin and Stem Cell ”

Mohammed Abu El-Hamd, Moustafa Adam El-Taieb, Faten Othman Ahmed, Ali Mohamed Younis, Mohamed Amer Ahmed Abdellatif, Eisa M. Hegazy

calcipotriol intralesional autologous platelet-rich plasma platelet-rich plasma alopecia areata Severity of Alopecia Tool PRP AA SALT

TLDR The combination of calcipotriol and PRP is the most effective treatment for alopecia areata.

This study evaluated the effectiveness of topical calcipotriol, intralesional autologous platelet-rich plasma (PRP) injection, and their combination in treating alopecia areata (AA) in 78 patients. Results showed significant reductions in the Severity of Alopecia Tool (SALT) scores across all treatment groups, with the combination treatment showing the greatest improvement (18.98 points), followed by the PRP group (6.87 points), and the calcipotriol group (3.73 points). The study concluded that all treatments were effective, with the combination therapy being the most effective.

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