Efficacy and Safety of a Drinkable Nutraceutical in Premenopausal Women with Telogen Effluvium: A 6-Month, Randomized, Multicenter, Double-Blind, Placebo-Controlled Study

November 2025 in “ Dermatology and Therapy ”

Claudia Bernárdez, Sebastian Podlipnik, Gillian E. Westgate, Ralf Paus, Laura Zamfir, Daniela Grohmann, Manuel Sáez Moya, Claudia Bernárdez, Sebastian Podlipnik, Gillian E. Westgate, Ralf Paus, Laura Zamfir, Daniela Grohmann, Manuel Sáez Moya

telogen effluvium nutraceutical Olistic Women anagen-to-catagen/telogen ratio

TLDR The drinkable supplement increased hair growth and was safe for women with hair loss.

The study assessed the efficacy and safety of a drinkable nutraceutical, Olistic Women, in 106 premenopausal women with telogen effluvium over 6 months. It was a randomized, double-blind, placebo-controlled trial with 53 women in each group. The active product significantly increased hair density to 27.31 hairs/cm² compared to 18.23 hairs/cm² in the placebo group by day 180 and improved the anagen-to-catagen/telogen (A:C/T) ratio from 8.20:1 to 14.19:1. The nutraceutical was well-tolerated with no adverse events, suggesting it is an effective and safe non-pharmacological strategy for managing telogen effluvium by targeting multiple biological pathways.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

40 / 40 results

research Recent Advances in Drug Development for Hair Loss

April 2025 in “International Journal of Molecular Sciences”

New treatments for hair loss show promise with advanced therapies and better targeting.

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Nutraceutical Supplement With Standardized Botanicals in Males With Thinning Hair

research A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Nutraceutical Supplement With Standardized Botanicals in Males With Thinning Hair

January 2025 in “Journal of Cosmetic Dermatology”

The supplement improved hair growth and quality in men with thinning hair and was safe to use.

The Proportion of Catagen and Telogen Hair Follicles in Occipital Scalp of Male Androgenetic Alopecia Patients: Challenging the Established Dogma

research The Proportion of Catagen and Telogen Hair Follicles in Occipital Scalp of Male Androgenetic Alopecia Patients: Challenging the Established Dogma

October 2024 in “Experimental Dermatology”

The belief about hair shedding phases is likely incorrect and needs reevaluation.

A Comprehensive Investigation of Biochemical Status in Patients with Telogen Effluvium: Analysis of Hb, Ferritin, Vitamin B12, Vitamin D, Thyroid Function Tests, Zinc, Copper, Biotin, and Selenium Levels

research A Comprehensive Investigation of Biochemical Status in Patients with Telogen Effluvium: Analysis of Hb, Ferritin, Vitamin B12, Vitamin D, Thyroid Function Tests, Zinc, Copper, Biotin, and Selenium Levels

August 2024 in “Journal of Cosmetic Dermatology”

Telogen effluvium is linked to deficiencies in iron, vitamin B12, and thyroid function.

research The Hormonal Background of Hair Loss in Non-Scarring Alopecias

February 2024 in “Biomedicines”

Hormones like androgens, estrogen, thyroid hormones, and stress hormones can contribute to hair loss, and treatments target these hormonal imbalances.

Efficacy of a Wheat Polar Lipid Complex in Reducing Hair Loss and Improving Hair Growth in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Study

research Efficacy of a Wheat Polar Lipid Complex in Reducing Hair Loss and Improving Hair Growth in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Study

November 2023 in “International Journal of Cosmetic Science”

Wheat polar lipid complex reduces hair loss and improves hair growth in women.

research Psychosocial Impact of Androgenetic Alopecia on Men: A Systematic Review and Meta-Analysis

August 2023 in “Psychology, Health & Medicine”

Hair loss (androgenetic alopecia) mildly to moderately affects men's quality of life but not significantly their mental health.

research Chronic Telogen Effluvium: Is It a Distinct Condition? A Systematic Review

1 citations , April 2023 in “American Journal of Clinical Dermatology”

Chronic telogen effluvium may not be a unique condition and could be confused with other types of hair loss.

research Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

104 citations , January 2023 in “Journal of Clinical Medicine”

A holistic approach is needed to effectively address hair loss by understanding and influencing the hair growth cycle.

research The Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss

November 2022 in “Life”

Natural products may help treat hair loss by promoting hair growth with fewer side effects.

research Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype

August 2022 in “Nutrients”

Nutritional supplements may help improve hair growth in female pattern hair loss.

research The Susceptibility of Disulfide Bonds to Modification in Keratin Fibers Undergoing Tensile Stress

11 citations , April 2022 in “Biophysical Journal”

Disulfide bonds in keratin fibers break more easily under stress, especially when wet, affecting fiber strength.

research Zinc in Dermatology

11 citations , April 2022 in “Journal of Dermatological Treatment”

Zinc can help treat skin conditions and hair loss, especially if there's a zinc deficiency.

research Skin, Hair, and Beyond: The Impact of Menopause

14 citations , April 2022 in “Climacteric”

Menopause causes dry skin, wrinkles, and hair changes, with hormone therapy helping but not recommended just for these issues.

research Measuring Patient Quality of Life Following Treatment for Alopecia

8 citations , July 2021 in “Patient Preference and Adherence”

Alopecia treatments improve life quality but side effects can lessen this benefit; better use of quality of life measures is needed.

research Safety and Efficacy of ALRV5XR in Women with Androgenetic Alopecia or Telogen Effluvium: A Randomised, Double-Blinded, Placebo-Controlled Clinical Trial

6 citations , June 2021 in “EClinicalMedicine”

ALRV5XR significantly improves hair density in women with hair loss and is well-tolerated.

research Telogen Effluvium: A Review of the Science and Current Obstacles

23 citations , January 2021 in “Journal of Dermatological Science”

The document concludes that we need more research to understand Telogen Effluvium and find effective treatments.

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations , July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

research Telogen Effluvium: A Review of the Literature

40 citations , May 2020 in “Cureus”

The conclusion is that treatments for Telogen Effluvium exist, but standard treatment guidelines are needed.

research Natural Hair Supplement: Friend or Foe? Saw Palmetto, A Systematic Review in Alopecia

8 citations , January 2020 in “Skin appendage disorders”

Saw palmetto supplements may modestly improve hair regrowth with few side effects, but more research is needed.

research Improvement of Cell Proliferation and Antioxidant Activity of Silymarin in Hair Follicles Dermal Papillae Isolated from the Human Scalp: Comparison with Vitamin C Effects

8 citations , January 2020 in “International Journal of Trichology”

Silymarin improves hair follicle health better than vitamin C by boosting cell growth and reducing oxidative stress.

research Telogen Effluvium: A Comprehensive Review

56 citations , August 2019 in “Clinical, Cosmetic and Investigational Dermatology”

The document concludes that Telogen Effluvium is a hair loss disorder that can be assessed with the modified wash test and may be treated with clobetasol foam, with patient management being important.

research The Role of Vitamins and Minerals in Hair Loss: A Review

134 citations , December 2018 in “Dermatology and Therapy”

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

research Hair Evaluation Method: Pull Test and Wash Test

4 citations , January 2017

The pull and wash tests are simple, cost-effective ways to diagnose hair loss severity and type.

Efficacy and Safety of a Dietary Supplement Containing a Lipid Co-Extract from Serenoa Repens and Pygeum Africanum for the Treatment of Androgenetic Alopecia in Women: Results of a Randomized, Double-Blind, Placebo-Controlled Clinical Trial

research Efficacy and Safety of a Dietary Supplement Containing a Lipid Co-Extract from Serenoa Repens and Pygeum Africanum for the Treatment of Androgenetic Alopecia in Women: Results of a Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2 citations , April 2016 in “Más dermatología”

The supplement with Serenoa repens and Pygeum africanum significantly increased active hair growth and decreased rest phase hair in post-menopausal women with hair loss, with only mild digestive side effects.

research Towards a Consensus on How to Diagnose and Quantify Female Pattern Hair Loss – The Female Pattern Hair Loss Severity Index (FPHL-SI)

26 citations , December 2015 in “Journal of The European Academy of Dermatology and Venereology”

New method measures female hair loss: Female Pattern Hair Loss Severity Index (FPHL-SI).

research Postpartum Telogen Effluvium

7 citations , January 2015 in “Journal of the European Academy of Dermatology and Venereology”

Only about 20% of women have hair loss after childbirth severe enough to be considered clinically significant.

research An Overview of Alopecias

53 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.

research The Changes in the Hair Cycle During Gestation and the Post-Partum Period

34 citations , May 2013 in “Journal of the European Academy of Dermatology and Venereology”

Hair growth slows and shedding increases after childbirth, but most women don't experience excessive hair loss.

research Methods of Hair Loss Evaluation: A Comparison of TrichoScan with the Modified Wash Test

14 citations , May 2013 in “Experimental Dermatology”

The modified wash test is better than TrichoScan® for diagnosing hair loss.

research Alterations in Hair Follicle Dynamics in Women

26 citations , January 2013 in “BioMed Research International”

Hormonal changes after childbirth and menopause can lead to women's hair loss and facial hair growth, with a need for better treatments.

research Unique Amino Acid Signatures That Are Evolutionarily Conserved Distinguish Simple-Type, Epidermal, and Hair Keratins

76 citations , December 2011 in “Journal of Cell Science”

Different keratin types have unique amino acid patterns that are evolutionarily conserved.

research Hormonal Changes in Menopause: Do They Contribute to a Midlife Hair Crisis in Women?

38 citations , December 2011 in “British Journal of Dermatology”

Menopause-related hormonal changes affect hair but are not the only cause of hair changes in middle-aged women.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research Seasonality of Hair Shedding in Healthy Women Complaining of Hair Loss

37 citations , January 2009 in “Dermatology”

Healthy women tend to lose more hair in July and April, and the least in February.

research Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations

100 citations , June 2006 in “British Journal of Dermatology”

Hair loss severity relates to increased miniaturization in female pattern hair loss.

research Nutritional Factors and Hair Loss

239 citations , July 2002 in “Clinical and Experimental Dermatology”

Low iron and L-lysine levels can cause hair loss in women, and increasing these nutrients can reduce hair shedding.

research Hair Density, Hair Diameter, and the Prevalence of Female Pattern Hair Loss

234 citations , February 2001 in “British Journal of Dermatology”

FPHL affects hair density and diameter, causing visible hair loss in older women.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

Hair follicle biology advancements may lead to better hair growth disorder treatments.

research Human Hair Keratins

90 citations , July 1993 in “Journal of Investigative Dermatology”

Similar Research

5 / 1000+ results

research A Novel Drinkable Food Supplement Formulation Reduces Hair Shedding and Increases the Percentage of Anagen Scalp Hair Follicles in Females with Hair Loss

November 2025 in “Journal of Clinical Medicine”

The drinkable supplement reduced hair shedding and increased hair growth in women.

research Efficacy Assessment of a Nutraceutical with a Marine Protein Complex in the Reduction of Female Telogen Effluvium

April 2017 in “Journal of dermatology & cosmetology”

The marine protein complex, Viviscal®, was found to effectively reduce hair loss and improve hair, skin, and nails quality in women.

research Evaluation of Tolerance and Trichological Efficacy of a Food Supplement in Men and Women with Telogen Effluvium-Like Disorder

December 2022 in “Cosmetics”

The food supplement improved hair growth and strength in people with a certain type of hair loss and had no major side effects.

research A Novel Nutraceutical Gummy for Hair Regrowth in Women: A Case Series

November 2024 in “SKIN The Journal of Cutaneous Medicine”

The gummy improved hair growth and reduced shedding in women.

research Treatment-Induced Hair Shedding (Dread Shed) Associated With Androgenetic Alopecia Therapies

November 2025 in “SKIN The Journal of Cutaneous Medicine”

"Dread shed" is common with minoxidil but less so with other hair loss treatments.