TLDR Minoxidil and nebivolol can help prevent aortic aging in diabetic mice.
The study investigates the effects of minoxidil and nebivolol on elastogenesis and elastolysis in diabetic db/db mice, aiming to reduce premature aging of the aortic wall. By treating these mice with the antihypertensive agents, researchers observed stimulation of elastogenesis and inhibition of elastolysis, which restored functional elastic fibers and brought blood pressure levels closer to normal. The treatments work by opening ATP-sensitive potassium channels and regulating the forkhead box transcription factor (FOXO1). The findings suggest that monitoring these pathways could help limit aortic aging and reduce hypertension, atherosclerosis, and aneurysms in diabetic patients.
17 citations
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June 2019 in “Cellular signalling” Minoxidil helps protect and rebuild elastic fibers in arteries, improving artery function, especially in older females.
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July 2018 in “American Journal of Physiology-heart and Circulatory Physiology” Minoxidil improves blood flow and vessel flexibility, potentially helping with vascular stiffness.
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June 2017 in “Rejuvenation Research” Minoxidil treatment increases aorta elasticity and reduces stiffness in aged mice, potentially helping with age-related heart issues.
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August 2013 in “Hypertension” Potassium channel openers help form elastic fibers in arteries and can treat elastin deficiency and hypertension.
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August 2008 in “Toxicology Letters” High doses of minoxidil can harm marmoset hearts and kidneys, possibly affecting humans similarly.
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May 2004 in “Journal of Clinical Hypertension” Minoxidil effectively treats severe hypertension, but watch for side effects.
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