Minoxidil Improves Vascular Compliance, Restores Cerebral Blood Flow, and Alters Extracellular Matrix Gene Expression in a Model of Chronic Vascular Stiffness

    July 2018 in “ American Journal of Physiology-heart and Circulatory Physiology ”
    Russell H. Knutsen, Scott C. Beeman, Thomas J. Broekelmann, Delong Liu, Kit Yee Tsang, Attila Kovacs, Li Ye, Joshua R. Danback, Anderson Watson, Amanda Wardlaw, Jessica E. Wagenseil, Joel R. Garbow, Michael Shoykhet, Beth A. Kozel
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    TLDR Minoxidil improves blood flow and vessel flexibility, potentially helping with vascular stiffness.
    The study found that minoxidil, a drug commonly used to treat hair loss, can improve vascular compliance, restore cerebral blood flow, and alter extracellular matrix gene expression in a model of chronic vascular stiffness. The drug was found to increase elastin expression and deposition, resulting in larger vessels and improved blood flow. The study suggests that minoxidil may have potential therapeutic benefits for individuals with vascular stiffness, including those with elastin insufficiency-mediated arteriopathy and age-related vascular stiffness. Further research is needed to determine the drug's potential as a treatment for these conditions.
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