EXPRESSION OF CONCERN: Dermal papilla cell‐secreted biglycan regulates hair follicle phase transit and regeneration by activating Wnt/β‐catenin

This study investigates the role of biglycan, a protein secreted by dermal papilla cells, in hair follicle (HF) cycle regulation and regeneration, particularly through the Wnt/β-catenin signaling pathway. Using C57BL/6 and nude mice, researchers found that biglycan is highly expressed during the anagen phase of HFs and that its local injection delays catagen progression and promotes HF regeneration by activating Wnt signaling. Additionally, biglycan knockdown in dermal papilla cells inactivated Wnt signaling, while its overexpression activated it. These findings suggest that biglycan is crucial for HF cycle transit and regeneration, making it a potential target for treating hair loss conditions.