TLDR Fibroblast and endothelial cell interactions are crucial in forming hypertrophic scars.
This study examines the interaction between fibroblasts and endothelial cells in hypertrophic scar formation using both in vitro and in vivo models, involving 13 patients with hypertrophic scars. It highlights the role of endothelial cells in enhancing fibroblast proliferation and migration through cytokine signaling, with elevated levels of VEGF, TGF-β, PDGF, and bFGF. The research demonstrates that these interactions contribute to increased vascularity and scar formation, with significant gene expression changes related to extracellular matrix organization and fibrosis. The findings suggest that targeting these molecular pathways could lead to new treatments for fibrosis and scarring.
21 citations
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December 2023 in “Bioengineering & Translational Medicine” Fibroblast and endothelial cell interactions are crucial in forming hypertrophic scars.
March 2023 in “International Journal of bioprinting” Zinc/silicon-infused hydrogel helps regenerate hair follicles.
488 citations
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July 2021 in “Cell” Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.
1160 citations
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November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
1 citations
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January 2024 in “Theranostics” Exosomes show promise for future tissue regeneration.
40 citations
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December 2015 in “Stem Cells International” Mesenchymal stem cells help improve wound healing by reducing inflammation and promoting skin cell growth and movement.
30 citations
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February 2022 in “Stem Cell Reviews and Reports” Stem cell treatments may improve burn wound healing.
1160 citations
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November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
48 citations
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March 2019 in “Frontiers in Physiology” Wounds on the face usually heal with scars, but understanding how some wounds heal without scars could lead to better treatments.
