Finasteride Influence on P-Glycoprotein Functional Activity

    December 2012 in “ I P Pavlov Russian Medical Biological Herald ”
    E. N. Yakusheva, И. В. Черных
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    TLDR Finasteride increases P-glycoprotein activity in the liver and kidney.
    The study investigated the effect of finasteride on the functional activity of the efflux transporter protein P-glycoprotein (Pgp) in rabbits. By analyzing the pharmacokinetics of the marker substrate fexofenadine, it was determined that a 14-day course of finasteride administration resulted in a tissue-specific increase in Pgp functional activity in the liver and kidney.
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