Frontal Fibrosing Alopecia: An Observational Single-Center Study of 306 Cases

The observational study conducted at the Hospital General Universitario in Ciudad Real, Spain, analyzed 306 patients diagnosed with Frontal fibrosing alopecia (FFA) from 2010 to 2021. The severity of FFA was found to correlate with the time of progression. Hypothyroidism was present in 22.9% of patients, and signs of lichen planopilaris were observed in 9.8% of patients. The study also found that 27.2% of patients had androgenetic alopecia, 21.5% had facial papules, and 63.3% experienced itching. Inflammatory signs were seen in 67.3% and 61.4% of patients, but these were not associated with disease severity. The study concluded that FFA may affect younger patients and is likely underdiagnosed in males, and suggested that an autoimmune mechanism may be involved in the pathogenesis of FFA.