The Genetic Landscape of Androgenetic Alopecia: Current Knowledge and Future Perspectives

    January 2026 in “ Biology
    Aakar Gupta, Daniel J. Dennis, Vasiliki Economopoulos, Vincent Piguet
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    TLDR Androgenetic alopecia is influenced by multiple genes and pathways, with genetic risk varying by population, and personalized treatments are being explored.
    The document reviews the genetic landscape of androgenetic alopecia (AGA), emphasizing its polygenic nature and the identification of numerous susceptibility loci. It highlights the need for diverse genetic studies due to variations in genetic risk across different populations and the distinct genetic determinants between male and female-pattern hair loss. The review discusses the role of genes like the androgen receptor and the potential influence of genetic variation on treatment response, though no clinical markers are validated yet. Advances in single-cell and multi-omic approaches are promising for understanding genetic risk and developing personalized treatments. Future research should focus on diverse, well-powered studies and integrating genomic data to improve diagnosis and treatment strategies for AGA.
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