Synergistic Delivery of Ginseng Exosomes and Biomimetic Melanosomes via Temporally Controlled Hydrogel Microneedles Restrain the Pathologic Triad of Vitiligo
March 2026
in “
Journal of Nanobiotechnology
”
ginseng exosomes biomimetic melanosomes hydrogel microneedles vitiligo methacrylated hyaluronic acid polydopamine nanoparticles glyceryl monostearate micelles oxidative stress inflammation melanocyte deficiency redox balance follicular stem cells melanocyte function keratinocyte function ginseng melanosomes microneedles hyaluronic acid nanoparticles micelles stem cells
TLDR A new microneedle treatment can effectively repigment skin in vitiligo.
The study introduces a novel treatment for vitiligo using hydrogel microneedles to deliver ginseng-derived exosomes (G-Exos) and biomimetic melanosomes (PDA@PEGs). This system targets oxidative stress, inflammation, and melanocyte deficiency, the pathogenic triad of vitiligo. The microneedles enable rapid release of PDA@PEGs and MMP-9-responsive release of G-Exos, promoting redox balance, inflammation suppression, and melanocyte protection. In murine models, the treatment achieved significant repigmentation within 3 weeks by activating follicular stem cells and enhancing melanogenic and antioxidant pathways. This approach offers a promising, minimally invasive method for vitiligo treatment.
