Hematological And Hepatic Effects Of Vascular Epidermal Growth Factor (VEGF) Used To Stimulate Hair Growth In An Animal Model

October 2013 in “ BMC dermatology ”

Laís Angelo Gnann, R. F. Castro, Ligia Ajaime Azzalis, David Feder, Fábio Ferreira Perazzo, Edimar Cristiano Pereira, Paulo César Pires Rosa, Virgínia Berlanga Campos Junqueira, Katya Cristina Rocha, Carlos D Aparecida Santos Machado, Francisco Camargo Paschoal, Luíz Carlos de Abreu, Vítor Engrácia Valenti, Fernando Luiz Affonso Fonseca

vascular epidermal growth factor VEGF VEGF liposomes hair growth hair density hair thickness topical gel biochemical analysis hematological analysis toxicity

TLDR VEGF gel increases hair growth but may have potential toxicity.

The study evaluated the effects of a topical gel with VEGF liposomes on hair growth and its toxicological aspects in 18 hamsters. Results showed that VEGF increased hair density and follicle diameter significantly. However, biochemical and hematological analyses revealed potential toxicity, with lower red blood cell and mean corpuscular hemoglobin values, and elevated AST, ALT, and alkaline phosphatase levels in VEGF-treated animals. Despite these findings, most blood parameters showed no significant differences except for a reduction in eosinophils. The study concluded that while VEGF effectively stimulated hair growth, further research was needed to confirm its safety.

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