The Hairless Gene in Androgenetic Alopecia: Results of a Systematic Mutation Screening and a Family-Based Association Approach

April 2002 in “ British Journal of Dermatology ”

Axel M. Hillmer, Rudolf Kruse, Fabio Macciardi, U. Heyn, Regina C. Betz, Thomas Ruzicka, Peter Propping, Markus M. Nöthen, Sven Cichon

hairless gene androgenetic alopecia genetic variability HR gene genetic variants AGA

TLDR Hairless gene not strongly linked to baldness.

This study investigated the potential involvement of the hairless (HR) gene in androgenetic alopecia (AGA) by analyzing the genetic variability of HR in individuals with AGA and their families. The study found some genetic variants that were associated with AGA, but the results were not significant after correcting for multiple testing. The study did not provide strong evidence for a significant role of HR in the development of AGA.

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The Hairless Gene in Androgenetic Alopecia: Results of a Systematic Mutation Screening and a Family-Based Association Approach

Research cited in this study

research Variant 1859G→A (Arg620Gln) of the Hairless Gene: Absence of Association with Papular Atrichia or Androgenetic Alopecia

research Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

research Reply

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