Head And Neck 3D Bioprinting: A Review On Recent Advancements In Soft Tissue 3D Bioprinting And Medical Applications

June 2025 in “ Journal of Functional Biomaterials ”

Iosif-Aliodor Timofticiuc, Ana Căruntu, Christiana Diana Maria Dragosloveanu, Andreea-Elena Scheau, Ioana Anca Bădărău, Argyrios Periferakis, Şerban Dragosloveanu, Andreea Cristiana Didilescu, Constantin Căruntu, Cristian Scheau

TLDR 3D bioprinting offers new ways to treat head and neck defects with bioinks that mimic natural tissues.

The review highlights recent advancements in 3D bioprinting for head and neck soft tissue applications, emphasizing its potential to improve traditional treatments by creating complex tissue structures with integrated sebaceous glands and hair follicles. It discusses the use of bioinks and various bioprinting techniques to enhance anatomical precision and biofunctionality, while addressing challenges such as biocompatibility, immune response, and vascularization. The review underscores the potential of 3D bioprinting to reduce reliance on human donors and improve patient outcomes, although further research is needed to overcome mechanical, metabolic, and integration challenges for clinical applications.

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