Homeodynamic Rejuvenation: An Adaptive Framework for Resetting Skin Aging

The article introduces Homeodynamic Rejuvenation as a framework for addressing skin aging by restoring the skin's ability to manage stress and recover efficiently, rather than merely reversing visible signs of aging. This approach emphasizes homeodynamic plasticity, which is the skin's capacity to maintain function under stress. It integrates homeodynamics with exposome biology to reactivate cellular systems responsible for stress sensing, repair, and recovery. Five core processes—intracellular quality control, regenerative competence, metabolic resilience, cellular integrity, and structural integrity—are crucial for maintaining skin function. Disruption of these processes leads to skin aging, with dermatoporosis as a severe outcome. Homeodynamic Rejuvenation is evaluated through dynamic perturbation–recovery kinetics, linking biological processes to functional and clinical outcomes, thus providing a framework for enhancing skin resilience.