A State-Of-The-Art Overview On (Epi)Genomics And Personalized Skin Rejuvenating Strategies

The document provides a comprehensive overview of advancements in (epi)genomics and personalized strategies for skin rejuvenation, emphasizing the potential of personalized medicine by leveraging genomic and epigenomic data. It discusses various molecular and cellular mechanisms, such as DNA methylation, stem cell therapy, and senolytics like Dasatinib and Quercetin, in combating skin aging. The review highlights the integration of artificial intelligence and machine learning in predicting skin aging and tailoring treatments. It also addresses the challenges in translating genetic reprogramming into clinical applications, the role of HOTAIR modulators, and the potential widespread adoption of these strategies. While classical treatments like tretinoin and laser therapies are well-established, emerging (epi)genomic strategies show promise but require further research and development due to limited human data and regulatory challenges.