Hydrogel-Based Strategies for the Prevention and Treatment of Radiation-Induced Skin Injury: Progress and Mechanistic Insights

Hydrogels are emerging as promising candidates for the prevention and treatment of radiation-induced skin injury (RISI), a common complication of radiotherapy. Due to their high water content, porous structure, and excellent biocompatibility, hydrogels facilitate tissue repair through antioxidation, anti-inflammation, angiogenesis, and tissue remodeling. This review highlights recent advances in hydrogel-based interventions, emphasizing their material classifications and mechanisms. Understanding these mechanisms aids in designing next-generation wound dressings and enhances the clinical potential of hydrogels in radiotherapy, potentially redefining therapeutic strategies for RISI.