Immortalized Human Hair Follicle-Derived Mesenchymal-Like Stromal Cells for Long-Term Production of Scalable Immunomodulatory and Regenerative Secretome
November 2025
in “
Stem Cell Research & Therapy
”
immortalized human hair follicle-derived mesenchymal-like stromal cells iHF-MSCs mesenchymal stromal cells regenerative secretome immunomodulatory secretome peripheral blood mononuclear cells regulatory T cells conditioned media cell proliferation cell migration tube formation antioxidant properties oxidative stress hyperglycemia-induced damage hair follicle stem cells MSC immune modulation regenerative medicine antioxidants
TLDR Immortalized hair follicle cells could be useful for regenerative medicine and treating inflammation and oxidative stress.
This study demonstrates the potential of immortalized human hair follicle-derived mesenchymal-like stromal cells (iHF-MSCs) for scalable production of immunomodulatory and regenerative secretomes. The research highlights the successful immortalization of HF-MSCs, particularly clones C18 and C26, which maintain multipotency and exhibit strong immunomodulatory capabilities by suppressing peripheral blood mononuclear cell proliferation and enhancing regulatory T cell induction. The iHF-MSC-derived conditioned media promotes cell proliferation, migration, and tube formation, showcasing regenerative potential. Additionally, these cells exhibit antioxidant properties, protecting against oxidative stress and hyperglycemia-induced damage. The findings suggest that iHF-MSCs could be a valuable resource for therapeutic applications in regenerative medicine, inflammatory, and oxidative stress-related disorders.
