Immunopharmacological Potential of Arctium Lappa L. in Immune-Mediated Skin Diseases: A Critical Review of Experimental and Clinical Evidence

Arctium lappa L., known as burdock, shows potential in treating immune-mediated skin diseases (IMSDs) such as psoriasis, atopic dermatitis, and alopecia due to its anti-inflammatory and immunomodulatory properties, primarily through its compounds arctiin and arctigenin. These compounds modulate key inflammatory pathways and have shown efficacy in preclinical studies, mostly involving in vitro and animal models. However, the lack of standardized extracts, dosing, and robust clinical trials limits the ability to confirm their efficacy and safety in humans. Future research should focus on conducting well-controlled clinical trials and exploring advanced drug delivery systems to enhance bioavailability and therapeutic potential.