The Necessity to Investigate In Vivo Fate of Nanoparticle-Loaded Dissolving Microneedles

February 2024 in “ Pharmaceutics ”

Ziyao Chang, Yuhuan Wu, Qiyun Yi, Junhuang Jiang, Guilan Quan, Chuanbin Wu, Xin Pan, Zhengwei Huang

nanoparticle-loaded dissolving microneedles transdermal drug delivery stratum corneum precision medicine

Nanoparticle-loaded dissolving microneedles (DMNs) offer significant potential for enhancing transdermal drug delivery by overcoming the stratum corneum barrier, combining the advantages of high payload and controlled release. Despite their promise in precision medicine, no such products have been approved due to a lack of understanding of their in vivo fate, which is a major obstacle to clinical translation. This review highlights the current research status and emphasizes the need to investigate the in vivo fate of these DMNs to advance their development and application.

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The Necessity to Investigate In Vivo Fate of Nanoparticle-Loaded Dissolving Microneedles

Research cited in this study

research A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch

research A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy

research Dissolving Microneedles: Applications and Growing Therapeutic Potential

research Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

research Biocompatible Nanoparticles and Vesicular Systems in Transdermal Drug Delivery for Various Skin Diseases

research Microneedle Applications in Improving Skin Appearance

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