Inhibition Of The CoREST Repressor Complex Promotes Wound Re-Epithelialization Through The Regulation Of Keratinocyte Migration

The study explores the role of the CoREST repressor complex in wound healing, focusing on the chromatin regulators HDAC1 and LSD1. It demonstrates that corin, a dual inhibitor of these enzymes, accelerates wound closure in a mouse model by enhancing re-epithelialization through increased keratinocyte migration and histone acetylation, specifically H3K9. Corin treatment was shown to enhance the expression of genes associated with cell migration, such as AREG, CD24, and EPHB2, without cytotoxic effects. The findings suggest that targeting the CoREST complex with corin could be a promising strategy for treating chronic wounds, although further research is needed to fully understand its mechanisms.